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Say_220919

 

 

 

 

 

Head : Say Viengchareun, PhD, HDR

Members: January 1st 2020

Permanent researchers:

Say Viengchareun, Research Engineer, IRHC, Inserm
Marc Lombès, Research Director, DR1, Inserm

Post-Docs:

Elena Carceller Zazo, Post-Doc, Alfonso Martin Escudero Fundation Fellowship

Clinicians:

Pascal Boileau, Professor-Clinician, PUPH, Paris-Saclay University
Eric Pussard, Associate Professor, Paris-Saclay University
Laetitia Martinerie, Associate Professor, Paris-Saclay University
Emmanuelle Motte-Signoret, Clinician, Poissy Saint Germain Hospital

Engineer – Technicians:

Julie Perrot, Assistant Engineer, AI, Inserm

Students:

Thi-An Vu, PhD student, Paris-Saclay University, MESRI Fellowship
Simon Travers, PhD student, Paris-Saclay University, Inserm Fellowship
Laura Atger-Lallier, Master 2 student, Paris-Saclay University
Coline Rouleau, Master 2 student, Paris-Saclay University

Thèmes

Mineralocorticoid and glucocorticoid signaling:

  • Mechanisms of regulation of the expression of the mineralocorticoid (MR) and glucocorticoid (GR) receptor
  • Post-transcriptional control of mineralocorticoid receptor expression by RNA binding proteins and microRNA
  • Identification of new MR  and GR variants
  • Interaction of MR and GR (heterodimerization) and with their transcriptional co-regulators: activation mechanism, dynamics, specificity

Pathophysiology of biosynthesis and corticosteroid signaling in newborns:

  • Water and sodium wastings in premature and term infants
  • Respiratory distress in preterm infants
  • Identification of new modulators of the biosynthesis of corticosteroid hormones
  • Analysis of plasma and urinary steroids by mass spectrometry (LC-MS/MS)
  • Implementation of translational and clinical studies (PREMALDO and MINIPREM clinical trials)
  • Congenital adrenal hyperplasia

These projects have the financial support of Inserm and University and of national (ANR) and European (IFCAH) funding agencies. They also benefit from the clinical expertise and patient cohorts of the Pediatric Endocrinology and Diabetology Service of the Robert Debré Hospital and of the Poissy Saint Germain hospital.

 

5 main publications:

Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice.
Dumeige L, Nehlich M, Viengchareun S, Perrot J, Pussard E, Lombès M, Martinerie L.
Exp Mol Med. 2020 Jan;52(1):152-165.

Urinary steroidomic profiles by LC-MS/MS to monitor classic 21-Hydroxylase deficiency.
Pussard E, Travers S, Bouvattier C, Xue QY, Cosson C, Viengchareun S, Martinerie L, Lombès M.

J Steroid Biochem Mol Biol. 2019 Nov 26;198:105553.

Impaired 11β-Hydroxysteroid Dehydrogenase Type 2 in Glucocorticoid-Resistant Patients.
Vitellius G, Delemer B, Caron P, Chabre O, Bouligand J, Pussard E, Trabado S, Lombes M.

J Clin Endocrinol Metab. 2019 Nov 1;104(11):5205-5216.

Corticosteroid receptors adopt distinct cyclical transcriptional signatures.
Le Billan F, Amazit L, Bleakley K, Xue QY, Pussard E, Lhadj C, Kolkhof P, Viengchareun S, Fagart J, Lombès M.

FASEB J. 2018 Oct;32(10):5626-5639.

Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control.
Viengchareun S, Lema I, Lamribet K, Keo V, Blanchard A, Cherradi N, Lombès M.

J Am Soc Nephrol. 2014 Oct;25(10):2213-21.