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Peter Kamenicky

 

 

 

 

 

Head : Pr Peter Kamenicky, MD, PhD

Members: January 1st 2020

Permanent researchers:

Peter Kamenicky, Professor, PUPH, Paris-Saclay University
Philippe Chanson, Professor, PUPH, Paris-Saclay University
Agnès Linglart, Professor, PUPH, Paris-Saclay University

Eric Baudin, Clinician, PH, Gustave Roussy Institute
Bruno Francou, Clinician, PH, Paris Hospital

Engineers – Technicians

Nataly Ladurelle, Research Engineer, IR2, Inserm
XXX, Assistant Engineer, AI, Inserm (to be recruted)

Students:

Fanny Chasseloup, PhD student, Paris-Saclay University, ARS Fellowship
Clément Janot, Master 2 student, Paris-Saclay University Plan Cancer ITMO Fellowship


Themes:

Ectopic expression of the Glucose-dependent Insulinotropic Polypeptide Receptor (GIPR) receptor in endocrine tumors:
  • Implication of GIPR in the tumorigenesis and secretory activity of somatotropic pituitary adenomas responsible for acromegaly
  • Research of the molecular mechanisms leading to the ectopic expression of GIPR in pituitary tumors and in adrenal lesions
 
Invasive behavior of pituitary tumors:
  • Analysis of the molecular actors involved in the invasion of the cavernous sinus by pituitary tumors using a pan-genomic approach
  • Identification of therapeutic targets to inhibit the invasive behavior of pituitary tumors

These projects are funded by the ANR JCJC Intégral and benefit from the clinical expertise and patient cohorts of the Department of Endocrinology and Reproductive Diseases of Bicêtre Hospital.

 

5 main publications:

Hypermethylator Phenotype and Ectopic GIP Receptor in GNAS Mutation-Negative Somatotropinomas.
Hage M, Chaligné R, Viengchareun S, Villa C, Salenave S, Bouligand J, Letouzé E, Tosca L, Rouquette A, Tachdjian G, Parker F, Lombès M, Lacroix A, Gaillard S, Chanson P, Kamenický P.
J Clin Endocrinol Metab. 2019 May 1;104(5):1777-1787.

Genomic Alterations and Complex Subclonal Architecture in Sporadic GH-Secreting Pituitary Adenomas.
Hage M, Viengchareun S, Brunet E, Villa C, Pineau D, Bouligand J, Teglas JP, Adam C, Parker F, Lombès M, Tachdjian G, Gaillard S, Chanson P, Tosca L, Kamenický P.
J Clin Endocrinol Metab. 2018 May 1;103(5):1929-1939.

Adrenal GIPR expression and chromosome 19q13 microduplications in GIP-dependent Cushing’s syndrome.
Lecoq AL, Stratakis CA, Viengchareun S, Chaligné R, Tosca L, Deméocq V, Hage M, Berthon A, Faucz FR, Hanna P, Boyer HG, Servant N, Salenave S, Tachdjian G, Adam C, Benhamo V, Clauser E, Guiochon-Mantel A, Young J, Lombès M, Bourdeau I, Maiter D, Tabarin A, Bertherat J, Lefebvre H, de Herder W, Louiset E, Lacroix A, Chanson P, Bouligand J, Kamenický P.
JCI Insight. 2017 Sep 21;2(18).

AIP mutations impair AhR signaling in pituitary adenoma patients fibroblasts and in GH3 cells.
Lecoq AL, Viengchareun S, Hage M, Bouligand J, Young J, Boutron A, Zizzari P, Lombès M, Chanson P, Kamenický P.
Endocr Relat Cancer. 2016 May;23(5):433-43.

Genetic mutations in sporadic pituitary adenomas–what to screen for?
Lecoq AL, Kamenický P, Guiochon-Mantel A, Chanson P.
Nat Rev Endocrinol. 2015 Jan;11(1):43-54.