The main project of our Unit is devoted to translational research focused on endocrine pathophysiology and hormone signaling. The three partners of Bicêtre campus associating clinicians, biologists and basic scientists are working together to develop better understanding of molecular and cellular endocrinology.
We pursue studies on the mechanism of action of hormones by analyzing their specific receptors and their molecular partners, their implication in endocrine and metabolic pathophysiology in humans. Using complementary approaches, associating cellular and molecular biology, molecular pharmacology, integrated physiology, genetic analysis, we aim at investigating two interdisciplinary research axes:
- “Steroid receptors and transcriptional coregulators” dedicated to investigate the expression and the tissue-specific regulation of steroid receptors (mineralocorticoid, glucocorticoid, progesterone, androgens) and of their molecular coregulators, which represent key factors of hormonal responsiveness in target organs (kidney, heart, endometrium, adipose tissues, testis). We are also interested in other nuclear receptors notably xenobiotic receptor and pituitary tumorigenesis.
- Reproduction and hormone regulation (including prolactin and growth hormone) of the hypothalamo-pituitary-gonad axis in the context of ovary and testis dysfunction or hypogonadotropic hypogonadism associated to puberty and fertility abnormalities.